Interleukin-7 treatment of PML in a patient with idiopathic lymphocytopenia

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Interleukin-7 treatment of PML in a patient with idiopathic lymphocytopenia.

OBJECTIVE To describe the compassionate use of interleukin-7 (IL-7) for treatment of progressive multifocal leukoencephalopathy (PML) in the setting of idiopathic CD8+ greater than CD4+ lymphocytopenia. METHODS A 66-year-old HIV-seronegative man presented with progressive language dysfunction. MRI showed hyperintense lesions in the left hemispheric white matter with mild contrast enhancement....

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Pulmonary nocardiosis in a patient with idiopathic CD4 T‐lymphocytopenia

Idiopathic CD4 T-lymphocytopenia (ICL) is a rare immunodeficiency characterized by low CD4 T-lymphocyte count, which usually manifests with opportunistic infections. Nocardia as an opportunistic pathogen infecting patients with this condition has rarely been reported. Here, we describe the case of a 46-year-old male who presented with lung mass and respiratory and systemic symptoms and was even...

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angiocentric nasal t-cell lymphoma in a patient with idiopathic cd4+ lymphocytopenia

idiopathic cd4+ lymphocytopenia is a rare combined immunodeficiency disease, characterized by low cd4+ t-cell count and increased susceptibility to opportunistic infections, autoimmunity and malignancies after exclusion of secondary forms of cd4 lymphocytopenia. here we present a 13-year old boy who was referred to our center because of destructive ulceration of soft and hard palates with exten...

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Idiopathic CD4 Lymphocytopenia

Idiopathic CD4 T lymphocytopenia (ICL) is a rare and severe condition with limited available data. We conducted a French multicenter study to analyze the clinical and immunologic characteristics of a cohort of patients with ICL according to the Centers for Disease Control criteria. We recruited 40 patients (24 female) of mean age 44.2 T 12.2 (19Y70) years. Patients underwent T-lymphocyte phenot...

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ژورنال

عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation

سال: 2016

ISSN: 2332-7812

DOI: 10.1212/nxi.0000000000000213